Hellboy was originally a monster summoned by the Nazis as a biological weapon, but fortunately he was rescued and helped by Professor Bloom. Under the teaching and training of the professor, Hellboy gradually grew up, and then joined the supernatural investigation and defense Bureau and became the ace of the Bureau.
One day, the witch Blood Queen, who had been suppressed for thousands of years, broke through the shelter. In order to revenge mankind, she summoned a group of terrible monsters from hell and captured London. Only Hellboy was able to fight against the blood queen. With the help of psychic girl Alice and Shangben, a hard and protracted battle began.