Dean is missing. Sam and Castiel are anxious to find him, but at this time, Rowena translated three materials to remove the mark of Cain in the book of damned. Castiel called Crowley and hoped he could help find these three materials.
When dealing with a vampire case, Dean killed his good friend Rudy because of the “Cain mark”. Therefore, Dean can’t stand his guilt. Dean calls death and hopes that death can kill himself. Death gives Dean a suggestion. He can banish dean to other space and make Dean never return to earth, but it needs Sam’s life.